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Semaglutide Side Effects: What to Expect & How to Manage Them

Majesta Health Medical TeamApril 2, 20265 min read

Starting any new medication comes with questions about side effects. With semaglutide, most side effects are mild and temporary — but it's important to know what to expect.

Common Side Effects

The most frequently reported side effects include:

  • Nausea — The most common side effect, especially when starting or increasing dose. Usually mild and improves within a few weeks.
  • Decreased appetite — This is actually part of how the medication works. Most patients view this as a benefit.
  • Constipation or diarrhea — Digestive changes are common initially as your body adjusts.
  • Headache — Occasional headaches may occur, especially in the first week.

    • Tips for Managing Side Effects

    1. Start low, go slow — Your doctor will start you on a lower dose and gradually increase it 2. Eat smaller meals — Your appetite will be reduced, so smaller portions feel more comfortable 3. Stay hydrated — Drink plenty of water throughout the day 4. Avoid fatty or heavy foods — Light, balanced meals are easier to tolerate 5. Communicate with your care team — If side effects are bothersome, we can adjust your dose

    When to Contact Your Doctor

    While most side effects are mild, contact your care team if you experience:

  • Severe or persistent nausea/vomiting
  • Signs of pancreatitis (severe abdominal pain)
  • Changes in vision
  • Signs of allergic reaction

    • Your Majesta care team is available 24/7 to address any concerns.

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